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“Imagination is more important than knowledge. For knowledge is limited, whereas imagination embraces the entire world, stimulating progress, giving birth to evolution

RELEVANT RECENT PUBLICATIONS

- What life means to Einstein, Albert Einstein (1929) -

  • Yang X., Peng Y., Jiang X., Lu X., Duan W., Zhang S., Dai N., Shan J., Feng Y., Li X., Cheng Y., Yang Y., Baugh L., Tell G., Wang D., Li M., "The regulatory role of APE1 in epithelial-to-mesenchymal transition and in determining EGFR-TKI responsiveness in non-small-cell lung cancer.", Cancer Med. (2018) Aug 14. doi: 10.1002/cam4.1717. [Epub ahead of print] PubMed PMID: 3010978.

  • Zaky A, Bouali-Benazzouz R, Favereaux A, Tell G., Landry M. "APE1/Ref-1 redox function contributes to inflammatory pain sensitization." Exp Neurol. (2018), 307:1-11.

  • Antoniali G, Serra F, Lirussi L, Tanaka M, D'Ambrosio C, Zhang S, Radovic S, Dalla E, Ciani Y, Scaloni A, Li M, Piazza S, Tell G., "Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism." Nat Commun. (2017), 8(1):797.

  • Malfatti MC, Balachander S, Antoniali G, Koh KD, Saint-Pierre C, Gasparutto D, Chon H, Crouch RJ, Storici F, Tell G., "Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2." Nucleic Acids Res. (2017), 45(19):11193-11212.

  • Pekhale K, Haval G, Perween N, Antoniali G, Tell G., Ghaskadbi S, Ghaskadbi S. "DNA repair enzyme APE1 from evolutionarily ancient Hydra reveals redox activity exclusively found in mammalian APE1." DNA Repair (Amst). (2017), 59:44-56.

  • Antoniali G, Malfatti MC, Tell G., "Unveiling the non-repair face of the Base Excision Repair pathway in RNA processing: A missing link between DNA repair and gene expression?" DNA Repair (Amst). (2017), 56:65-74.

  • Cesselli D, Aleksova A, Sponga S, Cervellin C, Di Loreto C, Tell G., Beltrami AP. "Cardiac Cell Senescence and Redox Signaling." Front Cardiovasc Med. (2017) 4:38. doi: 10.3389/fcvm.2017.00038.

  • Zhang S, He L, Dai N, Guan W, Shan J, Yang X, Zhong Z, Qing Y, Jin F, Chen C,  Yang Y, Wang H, Baugh L, Tell G., Wilson DM 3rd, Li M, Wang D. "Serum APE1 as a predictive marker for platinum-based chemotherapy of non-small cell lung cancer patients." Oncotarget (2016) 7(47):77482-77494.

  • Lirussi L, Antoniali G, D'Ambrosio C, Scaloni A, Nilsen H, Tell G., "APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation." Oncotarget. (2016) 7(18):26293-306.

  • Antoniali G, Marcuzzi F, Casarano E, Tell G., "Cadmium treatment suppresses DNA polymerase δ catalytic subunit gene expression by acting on the p53 and Sp1 regulatory axis." DNA Repair (Amst). (2015), 35:90-105.

  • Bortolussi G, Codarin E, Antoniali G, Vascotto C, Vodret S, Arena S, Cesaratto L, Scaloni A, Tell G., Muro AF. "Impairment of enzymatic antioxidant defenses is associated with bilirubin-induced neuronal cell death in the cerebellum of Ugt1 KO mice." Cell Death Dis. (2015), 6:e1739.

  • Poletto M, Malfatti MC, Dorjsuren D, Scognamiglio PL, Marasco D, Vascotto C, Jadhav A, Maloney DJ, Wilson DM 3rd, Simeonov A, Tell G., "Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties." Mol Carcinog. (2015), 55(5):688-704.

  • Tell G., Demple B. "Base excision DNA repair and cancer." Oncotarget. (2015), 6(2):584-5.

  • Grasso S, Tell G., "Base excision repair in Archaea: Back to the future in DNA repair." DNA Repair (Amst). (2014) 21C:148-157.

  • Poletto M, Lirussi L, Wilson DM 3rd, Tell G., "Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins." Mol Biol Cell. (2014) 25(10):1641-52.

  • Mantha AK, Sarkar B, Tell G., "A short review on the implications of base excision repair pathway for neurons: relevance to neurodegenerative diseases." Mitochondrion. (2014) 16:38-49.

  • Vascotto C, Lirussi L, Poletto M, Tiribelli M, Damiani D, Fabbro D, Damante G, Demple B, Colombo E, Tell G. "Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology." Oncogene. (2014) 33(22):2876-87.

  • Antoniali G, Lirussi L, Poletto M, Tell G., "Emerging Roles of the Nucleolus in Regulating the DNA Damage response: the non-canonical DNA repair enzyme APE1/Ref-1 as a paradigmatical example." Antioxid Redox Signal. (2014), 20(4):621-39.

  • Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G., "SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements." Mol Biol Cell. (2014), 25(4):532-47.

  • Tell G., Di Piazza M, Kamocka MM, Vascotto C. "Combining RNAi and in vivo confocal microscopy analysis of the photoconvertible fluorescent protein Dendra2  to study a DNA repair protein." Biotechniques. (2013), 55(4):198-203.

  • Cesaratto L, Codarin E, Vascotto C, Leonardi A, Kelley MR, Tiribelli C, Tell G., "Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines." PLoS One. (2013), 8(8):e70909.

  • Marasco D, Ruggiero A, Vascotto C, Poletto M, Scognamiglio PL, Tell G., Vitagliano L. "Role of mutual interactions in the chemical and thermal stability of nucleophosmin NPM1 domains." Biochem Biophys Res Commun. (2013) 430(2):523-8.

  • Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G., "Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin)." Biochem J. (2013), 452(3):545-57.

  • Tell G., Vascotto C, Tiribelli C., "Alterations in the redox state and liver damage: Hints from the EASL Basic School of Hepatology." J Hepatol. (2012), S0168-8278(12)00749-0. doi: 10.1016/j.jhep.2012.09.018.

  • Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat K, Scaloni A, Tell G., "Nucleolar accumulation of APE1 depends on charged Lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells." Mol Biol Cell. (2012), 23(20):4079-96.

  • Poletto M, Di Loreto C, Marasco D, Poletto E, Puglisi F, Damante G, Tell G., "Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers." Biochem Biophys Res Commun. (2012) 424(1):34-9.

  • Vascotto C., Bisetto E., Li M., Zeef LAH, D’Ambrosio C, Domenis R, Comelli M, Delneri D, Scaloni A, Altieri F, Mavelli I, Quadrifoglio F, Kelley MR, Tell G., "Knock-in reconstitution studies reveal an unexpected role of Cys65 in regulating APE1/Ref-1 subcellular trafficking and function." Mol Biol of The Cell (2011), 22(20):3887-901.

  • Bivi N, Picotti P, Müller LN, Romanello M, Moro L, Quadrifoglio F, Tell G., "Shotgun proteomics analysis reveals new unsuspected molecular effectors of nitrogen-containing bisphosphonates in osteocytes." J Proteomics. (2011), 74(7):1113-22.

  • Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, Tell G., "Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions." Nucleic Acids Res. (2010), 38(22):8239-56.

  • Tell G., Fantini D, Quadrifoglio F. "Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment." Cell Mol Life Sci. (2010) 67(21):3589-608.

  • Tell G., Wilson DM 3rd. "Targeting DNA repair proteins for cancer treatment." Cell Mol Life Sci. (2010), 67(21):3569-72.

  • Scaloni A, Tell G., "Mass spectrometry approaches for the redox characterization of protein cysteine residues the case of the transcription factor" Pax-8. Methods Enzymol. (2010), 473:227-50.

  • Deganuto M, Cesaratto L, Bellarosa C, Calligaris R, Vilotti S, Renzone G, Foti R, Scaloni A, Gustincich S, Quadrifoglio F, Tiribelli C, Tell G., "A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein." Proteomics (2010), 10(8):1645-57.

  • Tell G., Wilson DM 3rd, Lee CH. "Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?" Mol Cell Biol. 2010 Jan;30(2):366-71.

  • Vascotto C, Fantini D, Romanello M, Cesaratto L, Deganuto M, Leonardi A,Radicella JP, Kelley MR, D'Ambrosio C, Scaloni A, Quadrifoglio F, Tell G. "APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process." Mol. Cell Biol. (2009), 29(7):1834-54

  • Codarin E, Renzone G, Poz A, Avellini C, Baccarani U, Lupo F, di Maso V, Crocè SL, Tiribelli C, Arena S, Quadrifoglio F, Scaloni A, Tell G. "Differential proteomic analysis of subfractioned human hepatocellular carcinoma tissues." J. Proteome Res. (2009), 8(5):2273-84.

  • Tell G., Gustincich S. "Redox state, oxidative stress and molecular mechanisms of protective and toxic effects of bilirubin on cells." Curr. Pharm. Design (2009), 15(25):2908-14

  • Damante G., Scaloni A., Tell G. "Thyroid carcinoma: novel insights from proteomic studies." Expert Rev. Proteom. (2009), 6(4):363-76.

  • Bivi N, Romanello M, Harrison R, Clarke I, Hoyle DC, Moro L, Ortolani F, Bonetti A, Quadrifoglio F, Tell G., Delneri D. "Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection." Genome Biol. (2009), 10(9):R93.

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