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RESEARCH ACTIONS

  1. Molecular Mechanisms involved in the maintenance of Genomic Stability (BER pathway) and its relevance in tumor biology

  2. Non-canonical roles of DNA-repair enzymes in cancer biology associated to RNA-metabolism and nc-RNA decay and stability

  3. Development of small molecules inhibitors of DNA repair enzymes for combination therapy of tumors

  4. Development of human organoids from Colon cancer specimens for Precision Medicine

Organoid IF_TOPRO3_Actin.jpg

MODELS

  • BER enzymes (particularly APE1 and several DNA glycosylases)

  • HCC cancer

  • Breast cancer cell lines

  • Lung cancer cell lines

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